Wednesday, December 9, 2009

TSO helmith therapy fails to stop allergies Danish study

I got this from the helminth yahoo group post today. Very sad, result. I am glad someone did a study but I wish it had worked for allergies. So sad. So very sad. I wanted parasites to be a cure. The idea sounded so good. The parasite would secret substances (IL-10 analogs?) that would turn down the immune system allowing the parasite to survive and turning down allergy and autoimmune. What could be wrong with that? Apparently it does not work.
Now I itch so much worse. I took the sulfa drug about a half an hour ago. How bad will it get? Will the damn bacteria die with this dose or will I need to risk Stevens Johnson skin falling off tomorrow morning as well when the next dose is due?

Why do people have adverse reactions with hives? At least one percent of us do so why does it happen. When will someone find out and rescue us?

--- In, "Donna Beales" wrote:
> I came across this article & wondered if anyone on this list would care to comment. Apparently a well-structured trial revealed that T. suis had no effect on allergic rhinitis:
> 1. J Allergy Clin Immunol. 2009 Oct 2. [Epub ahead of print]
> Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind,
> placebo-controlled clinical trial.
> Bager P, Arnved J, Rønborg S, Wohlfahrt J, Poulsen LK, Westergaard T, Petersen
> HW, Kristensen B, Thamsborg S, Roepstorff A, Kapel C, Melbye M.
> Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
> BACKGROUND: Parasitic helminth infections can protect against allergic airway
> inflammation in experimental models and have been associated with a reduced risk
> of atopy and a reduced course of asthma in some observational studies. Although
> no clinical evidence exists to support the use of helminth therapy for allergic
> disease, the helminth Trichuris suis has demonstrated efficacy in treatment of
> inflammatory bowel disease.

OBJECTIVE: To determine efficacy of helminth therapy
> for allergic rhinitis.

METHODS: We conducted a double-blind, placebo-controlled,
> parallel group trial in which 100 subjects age 18 to 65 years with grass
> pollen-induced allergic rhinitis were randomly assigned to ingest a total of 8
> doses with 2500 live T suis ova or placebo with an interval of 21 days. The
> primary outcome was a change in mean daily total symptom score for runny, itchy,
> sneezing nose (maximum change, 9.0) or in percentage of well days during the
> grass pollen season.

RESULTS: Treatment with T suis ova (N = 49) compared with
> placebo (N = 47) caused transient diarrhea peaking at day 41 in 33% of
> participants (placebo, 2%), and increased eosinophil counts (P < .001) and T > suis-specific IgE (P < .05), IgG (P < .001), IgG(4) (P < .003), and IgA (P < > .001), whereas there was no significant change in symptom scores (0.0; 95% CI,
> -0.5 to 0.4; P = .87), well days (3%; 95% CI, -9% to 14%; P = .63), total
> histamine (P = .44), grass-specific IgE (P = .76), or diameter of wheal reaction
> on skin prick testing with grass (P = .85) or 9 other allergens.

> Repeated treatment with the helminth T suis induced a substantial clinical and
> immunologic response as evidence of infection, but had no therapeutic effect on
> allergic rhinitis.
> PMID: 19800680 [PubMed - as supplied by publisher]
> Donna Beales, MLIS
> Lowell General Hospital
> Health Science Library


Greg said...

TSO are not meant to survive in the human body as they are pig whipworm eggs, human whipworms survive for years because they alter the human immune sytem more effectively than pig whipworms. I would not look at this study as the definitive answer regarding effectiveness of Helminthic therapy in general, merely that pig whipworms are apparently not effective in controlling allergic rhinitis in humans. Most people that have tried human hookworm or human whipworm claim that it is effective in controlling their allergic rhinitis.

Steve said...

Sometimes our bodies decide that they just don't like something. When this happens, they let us know in a variety of ways. When we come into contact with an irritating substance, our bodies sometimes complain by itching, sneezing, coughing, and breaking out in rash. This lovely collection of symptoms is called 'allergies'.Allergy Therapy.